B-Complex is a comprehensive formula including Metafolin®, Methylcobalamin Vitamin B12, and Intrinsic Factor in its formulation. Metafolin® contains only the S isomer of 5-MTHF and has been shown to be the only form of folate to be able to cross the blood-brain barrier. Studies indicate that methylcobalamin, a coenzyme form of B12, may be better utilized and better retained in the body. Intrinsic factor is a protein produced by cells in the stomach lining and is needed for the intestines to absorb vitamin B12 efficiently.
B Complex with Metafolin®, manufactured by Douglas Laboratories, is a comprehensive B supplement
providing essential B vitamins and intrinsic factor, a nutrient necessary for optimal vitamin B12 absorption. B
Complex with Metafolin® is unique among other B complex vitamins as it contains Metafolin®, a patented,
natural form of (6S) 5-methyltetrahydrofolate (5-MTHF).
As co-enzymes, the B vitamins are essential components in most major metabolic reactions. They play an
important role in energy production, including the metabolism of lipids, carbohydrates, and proteins. B vitamins
are also important for blood cells, hormones, and nervous system function. † As water-soluble substances, B
vitamins are not generally stored in the body in any appreciable amounts (with the exception of vitamin B-12).
Therefore, the body needs an adequate supply of B vitamins on a daily basis.
Thiamin, riboflavin, and niacin are all essential coenzymes in energy production. Thiamin is converted quickly
into thiamin pyrophosphate, which is required for glycolytic and Krebs cycle reactions. Thiamin also appears to
be related to nerve impulse transmission. Riboflavin is a component of the coenzymes FAD and FMN, which
are intermediates in many redox reactions, including energy production and cellular respiration reactions.
Niacin is also a component of the coenzymes NAD and NADP, which are involved in energy production, as
well as biosynthetic processes.
Vitamin B-6 is a coenzyme in amino acid metabolism. It is necessary for the metabolism of homocysteine and
the conversion of tryptophan into niacin. Vitamin B-6 dependent enzymes are also needed for the biosynthesis
of many neurotransmitters, including serotonin, epinephrine, and norepinephrine. Methylcobalamin (vitamin B12) and folate are coenzymes in DNA and RNA metabolism. Both of these B vitamins assist in homocysteine
metabolism. Folate serves as a methyl donor and methylcobalamin as a coenzyme in the conversion of
homocysteine to methionine. Studies indicate that methylcobalamin, a coenzyme form of B12, may be better
utilized and better retained in the body. Metafolin® ® is a patented, natural form of (6S) 5-
methyltetrahydrofolate (5-MTHF). 5-MTHF is the naturally occurring, predominant form of folate commonly
found in cells and is essential for overall health, as it participates as a cofactor in a reaction that involves the
remethylation of homocysteine to methionine. Unlike synthetic folic acid, 5-MTHF can be used directly by the
body, without the need for an additional conversion via the enzyme (5,10-methylenetetrahydrofolate reductase
(MTHFR)). In certain populations, the body’s ability to convert folic acid to 5-MTHF by use of this enzyme may
be compromised due to genetic differences. Metafolin® contains only the S isomer of 5-MTHF and has been
shown to be the only form of folate to be able to cross the blood-brain barrier.
Biotin and pantothenic acid are also coenzymes essential for energy production from dietary fats,
carbohydrates, and proteins. Pantothenic acid is a component of coenzyme A and of phosphopantetheine, and
is therefore essential for Krebs cycle operation. Biotin is involved in many carboxylation reactions associated
with gluconeogenesis, the Krebs cycle, and fatty acid synthesis. †
Intrinsic factor is a protein produced by cells in the stomach lining. It is needed by the intestines to absorb
vitamin B12 efficiently. A deficiency of intrinsic factor can lead to vitamin B12 deficiency. Certain populations,
including the elderly and those unable to effectively produce intrinsic factor, can be more susceptible to B12
B Complex with Metafolin® may be useful for individuals who want to supplement with a complete array of B
vitamins and related nutrients.
B-COMPLEX W/METAFOLIN® AND INTRINSIC FACTOR