Biotin, also known as vitamin B7, is a critical water-soluble vitamin that is an essential co-factor for a number of metabolic carboxylation reactions, including carbohydrate, fat and protein metabolism.
Biotin is also known as vitamin B7, a critical water soluble vitamin that is an essential co-factor for a number of
metabolic carboxylation reactions, including carbohydrate, fat and protein metabolism. Biotin may provide
support for healthy glucose metabolism, nerve function and nail strength.†
Biotin forms a covalent bond to the following carboxylase enzymes: pyruvate carboxylase for glucose
metabolism, acetyl CoA carboxylase for fatty acid oxidation, and propinonyl-CoA carboxylase and ßmethylcrotonyl-CoA carboxylase for amino acid metabolism.
It is thought that biotin supports healthy glucose metabolism by stimulating glucose-induced insulin secretion
in pancreatic beta cells and by accelerating glycolysis in the liver and pancreas.† Biotin also enhances
muscle insulin sensitivity by increasing guanylate cyclase activity.† In a Japanese study, oral supplementation
of 3 mg biotin three times daily for one month supported healthy fasting glucose levels by 45%; no effect was
observed in subjects taking placebo. Immune cell function is also affected by biotin levels.† Effects of biotin on
gene expression are likely to modulate the response of immune cells to antigens. In vivo studies showed that
biotin increases the amount of mRNA encoding for interferon-?, interleukin-1, and 3-methylcrotonyl-CoA
Optimal levels of biotin support nerve function and play a role in activating acetyl CoA carboxylase, a
potentially rate-limiting enzyme in myelin synthesis.†
Clinical studies indicate that biotin may adjust the cellular arrangement of the nail bed, helping to reinforce the
keratin structure, promote strength and thickness, and reduce splitting.†
Biotin is a dietary supplement indicated for insulin sensitivity, nerve support and nail strength.
‡These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
BIOTIN 8 MG