Cysto Renew®, developed by Dr. Geo Espinosa, is a unique combination of ingredients designed to help calm the bladder and support healthy functioning of the urinary tract system. Each ingredient contributes to the health of the bladder glycosaminoglycan layer, nitric oxide production, healthy neuroendocrine system, and normal mast cell production that is important for a healthy functioning bladder.
Cysto Renew®, developed by Dr. Geo Espinosa, is a unique combination of ingredients designed to help calm
the bladder and support healthy functioning of the urinary tract system.† Each ingredient researched by Dr.
Espinosa, a naturopathic physician specializing in urology, contributes to the health of the bladder
glycosaminoglycan layer, nitric oxide production, healthy stress response, and normal mast cell production
that helps promote a healthy functioning bladder and normal urine frequency. †
The wall of the bladder is protected by a layer of molecules called proteoglycans, also called
glycosaminoglycans (GAG). Underneath the GAG layer is a layer of cells called the urothelium. In certain
bladder conditions such as IC, both of the layers can be disrupted. Once they feel the trigger by an insult in the
bladder, they send the message on to the submucosa, the layer right behind the urothelial cell and very rich in
nerves and mast cells. Activated mast cells release histamine and cytokines in the blood, which can lead to
chronic bladder irritation.
Chondroitin sulfate is a proteoglycan and has been found on the surface of the bladder lumen. It is also a
mast-cell inhibitor, and can help contribute to the strengthening of the GAG layer to support healthy bladder
integrity.† Research has concluded that the bladder lumenal and basal proteoglycans are associated with
Quercetin is a bioflavanoid that has positively shown in research to support bladder health by supporting the
normal release of histamine from mast cells and basophils, and eliciting a healthy immune response.†
Bromelain is a proteolytic enzyme that plays a role in healthy systemic inflammation and cytokine balancing.†
It is often combined with Quercetin for favorable absorption and synergistic actions.
L-Arginine and L-Citrulline are both amino acids that are precursors to nitric oxide production, a substance that
relaxes smooth muscles like those found in the bladder. Citrulline, an amino acid unrelated to citrus fruit, is
synthesized in body from arginine and ornithine and has been found to help relax blood vessels and release
nitric oxide. Studies reveal that nitric oxide levels may be decreased in certain bladder conditions.†
Bladders can be aggravated by stress and nerve signals. Rhodiola rosea is an herbal adaptagen that can
support the adrenal function and stress response.† Lemon balm, despite its name, is not from lemon but is a
perennial herb called Melissa officinalis that is related to the mint family. Lemon balm extract is considered to
be a mild calming agent and helpful for stress support.!!Magnesium can help the muscles relax and function
normally.† Aloe vera leaf is a type of glucosaccharide that may assist in the formation of the GAG layer in the
urinary tract system.
Cysto Renew® is indicated for individuals that desire a healthy renewal and calming effect of the bladder.
CYSTO RENEW® BLADDER SUPPORT‡