Metabolic Lean® is a novel weight management† formula that includes three branded and clinically studied ingredients—Meratrim® plant extract, Capsimax™ capsicum extract, and Zychrome® chromium complex. This special combination of ingredients may promote lipolysis, thermogenic activity and insulin function for overall metabolic support. The ingredients in Metabolic Lean® also help to support adiponectin levels which facilitate proper fat metabolism and healthy glucose regulation.‡†Provides weight management support as part of a healthy lifestyle with a reduced-calorie diet and regular exercise.
Metabolic Lean® by Douglas Laboratories is a novel weight management formula† that includes three branded
and clinically studied ingredients-- Meratrim® plant extract, Capsimax™ capsicum extract, and Zychrome®
chromium complex. This special combination of ingredients may improve lipolysis, thermogenic activity, and
insulin function. The ingredients in Metabolic Lean™ also help to increase adiponectin levels which facilitate
healthy fat metabolism and glucose regulation. ‡
• For individuals desiring weight management support.‡
FUNCTIONS AND MECHANISM OF ACTION
Meratrim® is a proprietary plant extract blend for weight management derived from two plants, Sphaeranthus
indicus and Garcinia mangostana, traditionally used in Southeast Asian culture. Meratrim has been shown in
two independent, randomized, double-blind, placebo-controlled clinical studies to significantly reduce body
weight, BMI, and waist circumference within 8 weeks when used in combination with a diet and exercise plan.
Meratrim appears to achieve this by modulating the accumulation of fat while simultaneously supporting
lipolysis. ‡ Toxicological studies on Meratrim have demonstrated a wide margin of safety.
In vitro studies demonstrate that Meratrim modulates the expression of biomarkers that control adipogenesis
and lipogenesis as follows:
• Active in the expression of the peroxisome proliferator-activated receptor gamma (PPAR)
hormone receptor. PPAR induces adipocyte-specific genes involved in the formation and growth
of fat cells.
• Active in the expression of adipocyte differentiation related protein (ADRP). This is a signaling
protein which facilitates the uptake of fatty acids to form lipid droplets and adipocyte
• Active in the expression of cluster of differentiation 36 (CD36)—a trans-membrane receptor that
facilitates fatty acid uptake by adipocytes.
• Perilipins are adipocyte proteins that are localized at the surface of the lipid droplet and inhibit fat
break down by restricting access of lipase to the lipid droplet.
Capsimax™ capsicum extract is a proprietary encapsulated form of premium, highly concentrated natural
capsicum fruit extract manufactured from hot red peppers. Capsaicinoids are a group of compounds which
cause the “heat” found in hot peppers. In fact, over the past 30 years, studies including animal and human
subjects support the potential of red hot capsicum and capsaicinoids as a safe, effective ingredient to aid in
weight management. Benefits of capsicum and capsaicinoids in animal and human studies have shown that it
helps manage appetite, supports healthy metabolism to burn calories, and helps induce thermogenesis.
Capsimax™ is a patent-pending encapsulated form of premium, highly concentrated natural capsicum extract.
Using a proprietary matrix, Capsimax capsicum extract gives users the maximum effectiveness of
capsaicinoids without any oral or gastric irritation, thus solving the problem of capsicum compliance. ‡
Zychrome® is a unique, patent-pending chromium complex consisting of chromium, niacin and L-cysteine
(chromium dinicocysteinate). Seventeen chromium complexes were screened in preclinical studies in order to
arrive at the complex found in Zychrome. In vitro and in vivo studies demonstrated that Zychrome is more efficacious than other forms of chromium in supporting healthy fasting glucose levels, glycated hemoglobin
levels (HbA1c), insulin levels, CRP, MCP-1, ICAM-1 and oxidative stress levels. These effects of Zychrome
are mediated by the regulation of cell signal transduction pathways associated with insulin function, and
glucose control. A randomized, double-blind, placebo-controlled clinical study showed that Zychrome
significantly modulated the levels of insulin and insulin resistance as well as the cytokine TNF and protein
carbonyl content, a marker of oxidative stress. Toxicological studies have demonstrated a wide margin of