ULTRA PREVENTIVE 50+

Ultra Preventive® 50+ is specially formulated with important vitamins, minerals, antioxidants and a proprietary fruit blend to support healthy aging in adults age 50+. This product features CoQ10 for metabolic energy and heart health, lutein and zeaxanthin for healthy vision, lycopene for cellular support, bioavailable B vitamins, and Neurophenol®, a proprietary blueberry and grape seed extract blend clinically studied for memory in healthy aging adults.‡ These EZ Swallow tablets include a natural, plant-based vanilla-flavored tablet coating for ease of swallowing. INDICATIONS A unique multivitamin/mineral specially formulated for cognition, vision, and healthy aging. ‡ FUNCTIONS Ultra Preventive® 50+ has been carefully developed to contain the right proportions and bioavailable forms of vitamins, minerals, antioxidants and other nutrients to support foundational health, cellular energy, vision, and cognition.‡ The body’s ability to maintain high ubiquinone (coenzyme Q10) levels naturally declines with age. CoQ10 is an important rate-limiting cofactor in the mitochondrial electron transport chain, in which adenosine triphosphate (ATP) is generated to produce metabolic energy. Since nearly all cellular activities are dependent upon metabolic energy, CoQ10 is essential for the health of tissues and organs with a high metabolic demand, especially the heart.‡ Lutein and zeaxanthin are important antioxidants in the macula of the eye. Recent studies performed by the NIH National Eye Institute have underscored the importance of these carotenoids in macular function, indicating that a dose of 10 mg lutein and 2 mg zeaxanthin offers macular health benefits. Lycopene is another carotenoid that provides antioxidant and cellular support for prostate, lung, cervical, breast and cardiovascular health. ‡ Berries are rich in beneficial phytochemicals known as polyphenols. It is well-documented that blueberries and fruit polyphenols play a significant role in cognitive function as we age. Ultra Preventive® 50+ features Neurophenol®, a proprietary blend of standardized wild blueberry and grape seed extracts. The active polyphenols in Neurophenol® include flavonoids such as anthocyanins and phenolic acids, resveratrol, and proanthocyanidin dimers and oligomers (also known as oligomeric proanthocyanidins, or OPCs). ‡ Human, animal and cellular studies suggest that Neurophenol® supports neuronal function, at least in part by supporting antioxidant defenses, cytokine balance and healthy gene expression. Animal research suggests that Neurophenol® may also support spatial memory, which is essential for recording information about orientation in the environment.‡ In a recent multi-national study of 200 older adults, Neurophenol® provided significant support for cognitive performance and memory at a dose of 600 mg per day over a six-month period. This provided significant support for episodic memory and verbal recognition memory, which reflect the ability to recognize previous events. Neurophenol® also helped to maintain a healthy cognitive age. These findings were significant in the lowest quartiles of initial cognitive performance. Neurophenol® provided significant support for episodic memory and verbal recognition memory (Figure 1). Neurophenol® also promoted the ability to encode and retrieve verbal information (Figure 2). For both outcomes, significant support was evident in the lowest quartiles of initial performance (Figures 1-3). These actions may be explained, in part, by modulation of the expression of genes involved in neuronal plasticity (Figure 4).

This formula contains methylated B vitamins to support cellular energy and the methylation pathways that influence mood, energy and homocysteine levels. This product contains three important forms of vitamin B12. Hydroxycobalamin is a precursor of vitamin B12 that is converted in the body to both methylcobalamin and adenosylcobalamin. While methylcobalamin is found in the cytosol of cells and predominates in blood and other fluids, adenosylcobalamin is the major form of vitamin B12 stored in the mitochondria of cellular tissues.‡ L-methylfolate (5-MTHF) is the naturally occurring, predominant form of folate commonly found in cells and is essential for overall health, as it participates as a cofactor in a reaction that involves the remethylation of homocysteine to methionine. Unlike synthetic folic acid, L-methylfolate can be used directly by the body, without the need for an additional conversion via the enzyme 5, 10-methylenetetrahydrofolate reductase (MTHFR). ‡ This formula also provides 20 mg of zinc, a mineral that is important in aging adults. Vitamin A is provided as a combination of provitamin A (beta carotene) and preformed vitamin A (retinyl palmitate), to help maintain vitamin A status to accommodate lower conversion efficiency in some individuals.‡

Ultra Preventive® 50+ 2 Daily EZ Swallow multivitamin/mineral tablets PRODUCT DATA DOUGLAS LABORATORIES® 11/2019 FORMULA (#202547) Serving Size 2 tablets Vitamin A …………………………………….……….. 2,100 mcg (as 70% beta carotene and 30% Vitamin A palmitate) Vitamin C (as ascorbic acid) ....................................... 120 mg Vitamin D3 (as cholecalciferol).......................25 mcg (1000 IU) Vitamin E (as d-alpha-tocopheryl succinate)...................65 mg Thiamine (as Thiamine HCl).......................................... 25 mg Riboflavin (as Riboflavin-5-phosphate).......................... 10 mg Niacin/Niacinamide........................................................ 30 mg Vitamin B-6 (as pyridoxal-5-phosphate)........................ 10 mg Folate (as Metafolin®, L-5-MTHF).……...............667 mcg DFE (400 mcg L-5-MTHF) Vitamin B-12 …………………………………………….350 mcg (as methylcobalamin/adenosylcobalamin/hydroxycobalamin) Biotin ..........................................................................300 mcg Pantothenic Acid (as d-calcium pantothenate).............. 25 mg Choline (from choline bitartrate) …................................. 60 mg Calcium (as Calcium Citrate/Malate Complex)............... 50 mg Iodine (as potassium iodide). .....................................150 mcg Magnesium (as magnesium citrate)...............................50 mg Zinc (as Opti-Zinc, monomethionine) .............................20 mg Selenium (as amino acid chelate) ............................. 100 mcg Chromium (as amino acid chelate) .............................120 mcg Molybdenum (as amino acid chelate ).........................100 mcg Potassium (as Potassium citrate)…. ............................. 30 mg Proprietary Neurophenol® blend...............................300 mg Providing 85 mg of flavonoids (flavan-3-ols, phenolic acids, flavonols, anthocyanins, resveratrol) from: Grape extract (Vitis vinifera, fruit) and Wild Blueberry Extract (Vaccinium angustifolium, fruit) Co-Enzyme Q10 (as ubiquinone)………………..……….50 mg Lutein (from marigold (Tagetes erecta) flower extract)...10 mg Lycopene (extracted from tomatoes)………….……….... 3 mg Zeaxanthin isomers (from marigold flower)…………….…2 mg Other ingredients: Microcrystalline cellulose, coating (hydroxypropyl methylcellulose, starch (rice), gum acacia, glycerine, natural vanilla flavor, fruit and vegetable juice (natural colorant), spirulina extract (natural colorant)), croscarmellose sodium, hydroxypropyl cellulose, ascorbyl palmitate, stearic acid and silica OptiZinc® is a trademark of InterHealth N.I. Metafolin® is a registered trademark of Merck KGaA, Darmstadt, Germany. Neurophenol® is a registered trademark used with permission. Gluten-free, Non-GMO SUGGESTED USE Adults take 2 tablets daily with food or as directed by a healthcare professional. Ultra Preventive® 50+ can be combined with Optimized Curcumin with Neurophenol® by Douglas Laboratories to provide the clinical dose of 600 mg of Neurophenol® for memory support. ‡